Clinicians at David Grant Medical Center have led advances in the use of Resuscitative Endovascular Balloon Occlusion of the Aorta, in our understanding of the effects of energy drink consumption and in our long-term expectations for the health of combat survivors. Research performed at David Grant Medical Center is intended to project benefits of American innovative care around the globe. Current research focuses are: Austere Environment Trauma Resuscitation, Traumatic Brain Injury, Evidence-Based Practice, Graduate Medical Education, Fitness and Nutrition, Hyperbaric Medicine, Cardiovascular Medicine and Military-Specific Health Care. Results from these studies can be accessed using the links below.

David Grant USAF Medical Center Research:

Resuscitative Endovascular Balloon Occlusion of the Aorta

• Reperfusion repercussions: A review of the metabolic derangements following resuscitative endovascular balloon occlusion of the aorta
• Resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhagic shock and blunt thoracic injury
• Automated Partial Versus Complete Resuscitative Endovascular Balloon Occlusion of the Aorta for the Management of Hemorrhagic Shock in a Pig Model of Polytrauma: a Randomized Controlled Pilot Study
• The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for non-traumatic cardiac arrest: A review
• Resuscitative endovascular balloon occlusion of the aorta (REBOA) in a pediatric swine liver injury model: A pilot study
• Esmolol reduces myocardial injury induced by resuscitative endovascular balloon occlusion of the aorta (REBOA) in a porcine model of hemorrhagic shock
• Resuscitative Endovascular Balloon Occlusion of the Aorta: Review of the Literature and Applications to Veterinary Emergency and Critical Care
• Zone 3 REBOA does not provide hemodynamic benefits during nontraumatic cardiac arrest
• Not ready for prime time: Intermittent versus partial resuscitative endovascular balloon occlusion of the aorta for prolonged hemorrhage control in a highly lethal porcine injury model
• Effects of Extended Lower Extremity Cooling Following Zone 3 REBOA in a Porcine Hemorrhage Model
• Resuscitative endovascular balloon occlusion of the aorta in a pediatric swine model: Is 60 minutes too long?
• Resuscitative endovascular balloon occlusion of the aorta induced myocardial injury is mitigated by endovascular variable aortic control
• Lower extremity cooling reduces ischemia-reperfusion injury following Zone 3 REBOA in a porcine hemorrhage model
• Location is everything: The hemodynamic effects of REBOA in Zone 1 versus Zone 3 of the aorta
• Endovascular variable aortic control (EVAC) versus resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhage and ischemia reperfusion injury
• Automated variable aortic control vs. complete aortic occlusion in a swine model of hemorrhage
• Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock

Effects of Energy Drink Consumption

• A Survey of Energy Drink Consumption and Associated Adverse Effects in Air Force Personnel
• Impact of High Volume Energy Drink Consumption on Electrocardiographic and Blood Pressure Parameters: A Randomized Trial
• Randomized Controlled Trial of High-Volume Energy Drink Versus Caffeine Consumption on ECG and Hemodynamic Parameters
• The Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-Analysis
• Effects of Single and Multiple Energy Shots on Blood Pressure and Electrocardiographic Parameters
• Electrocardiographic and blood pressure effects of energy drinks and Panax ginseng in healthy volunteers: A randomized clinical trial
• Impact of High Volume Energy Drink Consumption on Electrocardiographic and Blood Pressure Parameters

Long-term Health Outcomes for Combat Soldiers

• Risk factors of persistent insomnia among survivors of traumatic injury: a retrospective cohort study
• Telomere Shortening and Accelerated Aging in US Military Veterans
• Longitudinal mental health outcomes of combat-injured service members
• The Enduring Health Consequences of Combat Trauma: a Legacy of Chronic Disease
• Hypertension in military veterans is associated with combat exposure and combat injury
• Persistent Opioid Use After Combat Injury and Subsequent Long-term Risk of Abuse: A Retrospective Cohort Study
• Associations of Initial Injury Severity and Posttraumatic Stress Disorder Diagnoses With Long-Term Hypertension Risk After Combat Injury
• Presenting hypertension, burn injury, and mortality in combat casualties
• Hypertension after injury among burned combat veterans: A retrospective cohort study
• Retrospective Analysis of Long-Term Outcomes After Combat Injury: A Hidden Cost of War

Austere Environment Trauma Resuscitation

• Improvised Field Expedient Method for Renal Replacement Therapy in a Porcine Model of Acute Kidney Injury
• Pharmacokinetics of Tranexamic Acid Given as an Intramuscular Injection Compared to Intravenous Infusion in a Swine Model of Ongoing Hemorrhage
• Pharmacokinetics of Tranexamic Acid via Intravenous, Intraosseous, and Intramuscular Routes in a Porcine (Sus scrofa) Hemorrhagic Shock Model
• Point-of-Care Urinary Biomarker Testing for Risk Prediction in Critically Injured Combat Casualties
• Renal Replacement Therapy Capability for the Treatment of Combat-Associated Acute Kidney Injury: A Historical Perspective to Plan for Future Conflicts
• Hyperkalemia and Dialysis in the Deployed Setting
• A Novel Perfusion System for Damage Control of Hyperkalemia in Swine
• Field and en route resuscitative endovascular occlusion of the aorta: A feasible military reality?
• The Role I Resuscitation Team and Resuscitative Endovascular Balloon Occlusion of the Aorta
• Field and en route REBOA: A feasible military reality?
• A Modern Case Series of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in an Out-of-Hospital, Combat Casualty Care Setting

Trauma Resuscitation

• Improvised Field Expedient Method for Renal Replacement Therapy in a Porcine Model of Acute Kidney Injury
• Extracorporeal potassium binding for the management of hyperkalemia in an anephric model of crush injury
• Renal effects of three endoaortic occlusion strategies in a swine model of hemorrhagic shock
• Using the injury severity score to adjust for comorbid trauma may be double counting burns: Implications for burn research
• Hyperkalemia in Combat Casualties: Implication for Delayed Evacuation
• The pitfalls of resuscitative endovascular balloon occlusion of the aorta: Risk factors and mitigation strategies
• Coagulopathy and Mortality in Combat Casualties: Do the Kidneys Play a Role?
• Presenting hypertension, burn injury, and mortality in combat injuries
• Red tides: Mass casualty and whole blood at sea
• Renal Replacement Therapy Capability for the Treatment of Combat-Associated Acute Kidney Injury: A Historical Perspective to Plan for Future Conflicts
• A novel model of highly lethal uncontrolled torso hemorrhage in swine
• Combat Casualties and Severe Shock: Risk Factors for Death at Role 3 Military Facilities
• Comparison of direct site endovascular repair utilizing expandable polytetrafluoroethylene stent grafts versus standard vascular shunts in a porcine (Sus scrofa) model
• Multicenter retrospective study of noncompressible torso hemorrhage: Anatomic locations of bleeding and comparison of endovascular versus open approach
• Incremental balloon deflation following complete resuscitative endovascular balloon occlusion of the aorta results in steep inflection of flow and rapid reperfusion in a large animal model of hemorrhagic shock
• Small changes, big effects: The hemodynamics of partial and complete aortic occlusion to inform next generation resuscitation techniques and technologies
• Direct-site endovascular repair (DSER): A novel approach to vascular trauma
• Design of a cost-effective, hemodynamically adjustable model for resuscitative endovascular balloon occlusion of the aorta (REBOA) simulation
• Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma
• Emerging Endovascular Therapies for Non-Compressible Torso Hemorrhage
• Extending resuscitative endovascular balloon occlusion of the aorta: Endovascular variable aortic control in a lethal model of hemorrhagic shock
• Extending the golden hour: Partial resuscitative endovascular balloon occlusion of the aorta in a highly lethal swine liver injury model
• Comparison of AlloDerm and AlloMax tissue incorporation in rats

Traumatic Brain Injury

• High Versus Low Volume Fluid Resuscitation Strategies in a Porcine Model (Sus scrofa) of Combined Thermal and Traumatic Brain Injury
• Neuroimaging of brain trauma
• Perfusion Imaging in Acute Traumatic Brain Injury
• The effect of resuscitative endovascular balloon occlusion of the aorta, partial aortic occlusion and aggressive blood transfusion on traumatic brain injury in a swine multiple injuries model

Critical Care

• Endocrine Effects of Simulated Complete and Partial Aortic Occlusion in a Swine Model of Hemorrhagic Shock
• Endovascular Perfusion Augmentation for Critical Care: Partial Aortic Occlusion for Treatment of Severe Ischemia-Reperfusion Shock
• Presenting hypertension, burn injury, and mortality in combat casualties
• Acute Kidney Injury in Critically Injured Combat Veterans: A Retrospective Cohort Study
• Review of 54 Cases of Prolonged Field Care
• Urinary Biomarkers are Associated with Severity and Mechanism of Injury
• Reciprocal Risk of Acute Kidney Injury and Acute Respiratory Distress Syndrome in Critically Ill Burn Patients
• Rhabdomyolysis among critically ill combat casualties: Associations with acute kidney injury and mortality
• The potential utility of urinary biomarkers for risk prediction in combat casualties: a prospective observational cohort study
• A pilot study of chest tube versus pigtail catheter drainage of acute hemothorax in swine
• Damage control operations in non-trauma patients: Defining criteria for the staged rapid source control laparotomy in emergency general surgery
• A comparison of acute respiratory distress syndrome outcomes between military and civilian burn patients

Evidence Based Practice/Continuous Process Improvement

• Implementing Evidence-Based Practice Facilitators: A Case Series
• Clinical Research and Practice Collaborative: An Evidence-Based Nursing Clinical Inquiry Expansion
• Confronting Challenges in Reducing Heart Failure 30-Day Readmissions: Lessons Learned With Implications for Evidence-Based Practice
• Implementing Evidence-Based Neonatal Skin Care With Parent-Performed, Delayed Immersion Baths
• Improving Performance of Mammographic Breast Positioning in an Academic Radiology Practice

Graduate Medical Education

• Development of a porcine model of emergency resternotomy at a low-volume cardiac surgery centre
• Facial Cosmetic Surgery Training in American Oral and Maxillofacial Surgery Residency Programs
• A novel flight surgeon training model at a joint military and civilian surgical residency program
• Design of a cost-effective, hemodynamically adjustable model for resuscitative endovascular balloon occlusion of the aorta (REBOA) simulation
• Comparison of a ferret model with an inanimate simulator for training novices in techniques for intubating neonates

Fitness & Nutrition

• Effectiveness of Lifestyle Interventions in an Active Duty Air Force Population
• Effectiveness of an Injury Prevention Warm-up for Unit Physical Training: A Case Series of Two Flying Squadrons
• Training for the Air Force fitness assessment: The experience of postpartum women
• Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial
• Reduction of Fasting Blood Glucose and Hemoglobin A1c Using Oral Aloe Vera: A Meta-Analysis
• Impact of avocado-enriched diets on plasma lipoproteins: A meta-analysis

Hyperbaric Medicine

• The Effects of Hyperbaric Oxygen on Rheumatoid Arthritis: A Pilot Study
• Pain improvement in rheumatoid arthritis with hyperbaric oxygen: report of three cases

Facial Procedures

• Patient Preference for Preprocedural Anesthetic Prior to Facial Cosmetic Injectable Fillers

Cardiovascular Medicine

• Differences in glucose level between right arm and left arm using continuous glucose monitors
• Current concepts in repair of extremity venous injury
• Impact of Antihypertensive Agents on Central Systolic Blood Pressure and Augmentation Index: A Meta-Analysis
• Technical and early outcomes using ultrasound-guided reentry for chronic total occlusions
• Quantitative modeling of the accuracy in registering preoperative patient-specific anatomic models into left atrial cardiac ablation procedures
• Impact of enhanced external counterpulsation on Canadian Cardiovascular Society angina class in patients with chronic stable angina: A meta-analysis

Pediatric Trauma Resuscitation

• Does the pediatric hemodynamic cliff exist in response to hemorrhagic shock?
• Elective pediatric surgical care in a forward deployed setting: What is feasible vs. what is reasonable
• Imaging of pediatric pathology during the Iraq and Afghanistan conflicts
• Clearly defining pediatric massive transfusion: cutting through the fog and friction with combat data

Military Health Care

• Understanding Barriers to HPV Vaccination: Perspectives From Air Force Family Medicine Physicians and Active Duty Air Force Males
• Polycystic Ovary Syndrome in Active Duty Service Women: A Retrospective Analysis
• Challenges in Clinical Management of Radiation-Induced Illnesses During Exploration Spaceflight
• Considerations for Acute and Emergent Deployed Mental Health Patient Management and Theater Transports: A Scoping Review
• Resuscitation and Evacuation from Low Earth Orbit: A Systematic Review
• Ethical Considerations for Nursing Research With Military Populations
• Drone delivery of medications: Review of the landscape and legal considerations
• US Military Service and Racial/Ethnic Differences in Cardiovascular Disease: An Analysis of the 2011-2016 Behavioral Risk Factor Surveillance System
• Sun exposure knowledge and practices survey of maintenance squadrons at Travis AFB
• Efficacy of medical grade honey against multidrug-resistant organisms of operational significance: Part I